Beilstein J. Org. Chem.2016,12, 1269–1301, doi:10.3762/bjoc.12.121
. As shown in this review, they play an important role in organophosphorus chemistry where phosphorus reagents are used as substrates for the synthesis of a wide range of phosphorylatedheterocycles. In this article, an overview about multicomponent reactions used for the synthesis of heterocyclic
compounds bearing a phosphonate group on the ring is given.
Keywords: multicomponent reactions; organophosphorus chemistry; phosphorus reagents; phosphorylatedheterocycles; Introduction
Heterocyclic rings are found in many naturally occurring compounds and they compose the core structures of many
phosphorylatedheterocycles is the condensation of an activated methylene component with a carbonyl compound followed by subsequent transformations such as intramolecular cyclization, Michael-type addition and hetero-Diels–Alder cycloaddition.
3.1 Domino Knoevenagel/phospha-Michael process
A convenient one-pot